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Common Gut Bacteria Linked to Parkinson’s Disease
A common gut bacteria may play a role in the development of Parkinson’s disease (PD) by causing aggregation of the alpha-synuclein protein, a key feature in the pathology of PD, a small study suggests.
Environmental factors as well as genetics are also suspected to play a role in PD etiology, although the exact cause remains unknown.
“Our findings indicate that specific strains of Desulfovibrio bacteria are likely to cause Parkinson’s disease,” study investigator Per Erik Saris, PhD, from the University of Helsinki, Finland, says in a news release.
The study was published online online May 1 in Frontiers in Cellular and Infection Microbiology.
No Clinical Implications
Reached for comment, James Beck, PhD, chief scientific officer at the Parkinson’s Foundation, cautioned that “this research is in a very early stage, uses a nonvertebrate animal model, and the number of participants is small.
“Understanding the role of the gut microbiome in influencing PD is in its infancy. These are important steps to determining what ― if any ― link may be between gut bacteria and PD,” Beck told Medscape Medical News.
“Right now, there are no implications for the screening/treatment of carriers,” Beck said.
“It seems that a lot of people, whether with PD or not, harbor Desulfovibrio bacteria in their gut. More research is needed to understand what is different between the Desulfovibrio bacteria of people with PD vs those who do not have PD,” Beck added.
The study was supported by the Magnus Ehrnrooth Foundation and the Jane and Aatos Erkko Foundation. Saris and Beck have disclosed no relevant financial relationships.
Front Cell Infect Microbiol. Published online May 1, 2023. Full text
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