Diet, Exercise Can Affect the Brain ‘at the Molecular Level,’ Reducing Amyloid Buildup

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Diet, Exercise Can Affect the Brain ‘at the Molecular Level,’ Reducing Amyloid Buildup



Modifiable risk factors, such as exercise and consuming a Mediterranean-style diet (MedDiet), can reduce amyloid plaque in patients with mild cognitive impairment (MCI), lowering their risk for conversion to Alzheimer’s disease, suggests new imaging research.
The small study of 44 participants with MCI or subjective memory impairment (SMI) showed that those with a higher adherence to a MedDiet had significantly lower positron emission tomography (PET) measures of amyloid plaques and tau tangles than those with a lower adherence.
In addition, the patients with MCI who reported higher levels of physical activity had lower PET measures of amyloid and tau binding, whereas those with a higher body mass index (BMI) had higher measures of binding.
“To date, there really hadn’t been a look at the molecular pathology of this disease before it’s diagnosed,” lead author David A. Merrill, MD, PhD, assistant clinical professor of psychiatry at the University of California-Los Angeles Health System, told Medscape Medical News.
“The findings, especially showing that those who more regularly ate a Mediterranean-style diet had lower levels of these plaques and tangles, represent ‘smoking gun’ evidence of the molecular fingerprint of this disease process — and that there’s less of this binding when you strive to live healthily,” added Dr Merrill.
The study is published in the September issue of the American Journal of Geriatric Psychiatry.

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