Dietary Supplement May Prevent Cognitive Decline

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Dietary Supplement May Prevent Cognitive Decline


A dietary supplement containing ingredients commonly found in health food stores appears to prevent the decline in brain structure and function typically seen in Alzheimer’s disease, the results of an animal study indicate.
In a mouse model of accelerated aging and severe cognitive decline, a combination of vitamins and minerals, as well as nutraceuticals, such as beta carotene, bioflavonoids, cod liver oil, flax seed, garlic, and green tea extract, not only maintained brain cell numbers and mass and cognitive function but also appeared to prevent deterioration of sight and smell.
The study was led by Jennifer Lemon, PhD, research associate in the Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.
She said that she was “shocked, along with everybody else” that a nutraceutical combination “that’s considered by most practitioners in the medical field to be either ineffective or benign can actually have such a profound effect on function.”
Dr Lemon told Medscape Medical News that she is nevertheless “optimistic” that the effects of the supplement will translate into humans. One of the main reasons is that “the supplement works on fundamental mechanisms that are pretty much ubiquitous across any organism that breathes air, essentially.”
These mechanisms, which include oxidative stress, inflammation, and mitochondrial dysfunction, “happen in a multitude of species as they get older” and are not “something that is specifically a human phenomenon that has been attempted to be recreated in a mouse model,” she noted.
The study was published online May 20 in Environmental and Molecular Mutagenesis.

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