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Excessive GI Risks Exceed Cardiovascular Gains in Using Aspirin
A new analysis based on a randomized trial suggests that all healthy middle-aged and older women should not be taking low-dose aspirin for primary prevention of CVD or colorectal cancer, since the risk of major gastrointestinal (GI) bleeding outweighs the prevention benefits.
However, prophylactic therapy with low-dose aspirin might be warranted for women over age 65 with a low risk of GI bleeding. Thirty-two such women over age 65 would need to take low-dose aspirin (100 mg every second day) for 15 years to prevent one event—nonfatal MI, nonfatal stroke, death from CVD causes, or invasive colorectal cancer.
The study, based on an analysis of data from the Women’s Health Study, was published online December 4, 2014 in Heart.
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