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Exercise Helps, Obesity Hinders Testosterone Replacement
Men with late-onset hypogonadism who exercise regularly benefit more from testosterone replacement therapy than those who remain sedentary, according to a new study.
Testosterone levels were significantly higher in the exercise group than in the sedentary group, and the resolution of hypogonadism symptoms was better in the exercise group, said Min Gu Park, MD, from the Department of Urology at Inje University in Seoul, South Korea. In addition, the benefits of exercise remained after replacement therapy was stopped.
In a separate study looking at predictors of poor response to testosterone therapy, investigators found that nonobese men are much more likely to achieve normal testosterone levels than obese men.
“Weight loss may be as important as prescribing testosterone in the management of low T,” said Ashley Winter, MD, a urology resident at Weill Cornell Medical College in New York City.
“What do we need to do to fix this? Clearly the answer is that patients have to eat more nutritious food and less garbage, exercise more, and take better care of themselves,” said briefing moderator Tobias Köhler, MD, MPH, associate professor of urology at Southern Illinois University School of Medicine in Springfield, who was not involved in either study.
“There is a clear benefit from testosterone replacement for men who have biochemically low levels,” he told Medscape Medical News. “If they get the right treatment, they’re going to lose weight, they’re going to improve metabolic parameters, and do better overall.”
American Urological Association (AUA) 2014 Annual Scientific Meeting: Abstracts MP48-02 (Park et al) and MP48-04 (Winter et al). Presented May 19, 2014.
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