Gum Disease and Increased Link to Many Cancers

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Gum Disease and Increased Link to Many Cancers


Brushing, flossing, and regular dental checkups appear to do much more than maintain a healthy smile. Now, a large prospective cohort study shows that postmenopausal women with a history of periodontal disease, including those who have never smoked, are at significantly increased overall risk for cancer as well as site-specific cancers, including lung, breast, esophageal, gallbladder, and melanoma skin cancers.
“Ours is the first study to report on the association between periodontal disease and gallbladder cancer risk in women or men,” say Jean Wactawski-Wende, PhD, from the State University of New York at Buffalo, and colleagues in an online report published August 1 in Cancer Epidemiology, Biomarkers & Prevention.
“Periodontal disease is preventable, manageable, and in many cases, treatable,” she emphasized, adding “it may be prudent for clinicians to advise all their patients to maintain good oral health. Men and younger women may consider these findings potentially relevant to them as well.”
The Centers for Disease Control and Prevention (CDC) estimate that 47% of adults 30 years of age and older in the United States have some form of periodontal disease, ranging from mild to severe. At age 65 years and older, however, 70% of adults have moderate to severe periodontal disease, according to the CDC.

Total Cancer Risk Increased by 14%  

The study involved almost 66,000 postmenopausal women in the United States, who were enrolled in the ongoing Women’s Health Initiative Observational Study (WHI-OS). During a mean follow-up of 8.32 years, the team identified 7149 cancers and found that periodontal disease history was associated with a 14% increased total cancer risk, with a multivariable-adjusted hazard ratio (HR) of 1.14.
Cancer Epidemiol Biomark Prev. Published online August 1, 2017.

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