High-Altitude Living Linked to Lower Alzheimer’s Risk

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High-Altitude Living Linked to Lower Alzheimer’s Risk


Individuals who live at higher altitudes may have a 50% lower risk of dying of Alzheimer’s disease (AD) compared with their counterparts living at lower altitudes, say US researchers in findings that may point to a number of potentially associated factors.
In an analysis of deaths from AD over a 1-year period in Californian counties, the investigators found that people living at the highest altitudes were approximately half as likely to die from AD as those living at the lowest altitudes.
“This analysis suggests that altitude of residence may impact the risk for dying of Alzheimer dementia,” the investigators, led by Stephen Thielke, MD, Geriatric Research, Education, and Clinical Center, Puget Sound VA Medical Center, in Seattle, Washington, write.
Although acknowledging that the findings should be interpreted “cautiously,” the researchers note that “altitude of residence might be associated with environmental, lifestyle, or health- related factors, which influence dementia rates. Oxygen levels might have direct long-term effects on brain physiology.”
The research was published online October 21 in JAMA Psychiatry.

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