Inflammation Predicts Metabolic Health, Not Size
Lean or Obese, Low Inflammation Predicts Metabolic Health
Adults with normal blood levels of inflammatory markers were likely to have favorable “metabolic health” whether they were lean or obese, a new study shows.
The concept of “metabolically healthy obesity” — that is, individuals with a body mass index (BMI) above 30 who do not have metabolic-syndrome factors that put them at risk for cardiovascular disease events — is not new, but is only now being more widely recognized by clinicians, say experts. Up to 35% of obese individuals may be metabolically healthy despite their size, the researchers write, but the true prevalence of this phenomenon is difficult to assess due to large disparities in defining metabolic health.
“From a public-health standpoint, we need better methods for identifying which obese people face the greatest risk of diabetes and heart disease,” says lead author Catherine M. Phillips, PhD, from University College Cork, Ireland, in a statement.
“Inflammatory markers offer a potential strategy for pinpointing people who could benefit most from medical interventions,” she observes.
The study was published online August 27 in the Journal of Clinical Endocrinology & Metabolism.
And obese individuals were up to 3.5 times more likely to be metabolically healthy if they had normal levels of certain biomarkers of inflammation than if they had abnormal levels.
Odds of Metabolically Healthy Obesity Associated With Favorable Inflammatory Marker Levels Among Obese Individuals
“The results of our study suggest that reduced inflammatory status increases the likelihood of metabolic health, particularly among obese subjects,” the researchers state.
These findings are of public-health and clinical significance in terms of screening and stratification based on metabolic-health phenotype to identify those at greatest cardiometabolic risk for whom appropriate therapeutic or intervention strategies should be developed.
Abstract
via Blogger http://chiropractic-lane.blogspot.com/2013/09/inflammation-predicts-metabolic-health.html
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