Inhaled Steroids May Make Pollution’s Effect on Asthma Worse

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Inhaled Steroids May Make Pollution’s Effect on Asthma Worse


Inhaled corticosteroids cannot adequately protect children with asthma from high levels of air pollution and may actually exacerbate the effects of pollutants, caution investigators in a clinical study.


The authors found that both long-term and short-term exposures to pollution were associated with decreased lung function and increased airway hyperresponsiveness among 1003 children with asthma who were enrolled in a trial comparing budesonide (Pulmicort, AstraZeneca) with nedocromil (which has since been withdrawn from the US market) or placebo.


Significantly, children receiving either budesonide or nedocromil had a more pronounced worsening of airway responsiveness with exposure to carbon monoxide (CO) than the children who were assigned to placebo, report Despo Ierodiakonou, MD, PhD, from the University of Groningen, the Netherlands, and colleagues in an article published online July 14 in the Journal of Clinical Allergy and Immunology.

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