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Kidney Stones May Up CHD Risk in Women, But Not Men
A history of kidney stones predicts later coronary heart disease (CHD) events in women independently of dietary calcium intake and many cardiovascular risk factors, but the same doesn’t seem to be true for men, according to a combined analysis of three large cohort studies.
Whether there is indeed a pathophysiologic relationship between nephrolithiasis and CHD events, especially one that varies by sex, remains a mystery, caution the authors, led by Dr Pietro Manuel Ferraro (Catholic University of the Sacred Heart, Rome, Italy). The authors speculate that the link is an “unknown inherent metabolic state” for which kidney stones are an early marker and CHD a later effect, or perhaps they have risk factors in common that were not accounted for in the analysis.
The analysis was published in the July 24/31, 2013 issue of the Journal of the American Medical Association.
The authors caution that the findings may not be generalizable beyond the predominantly white HPFS, NHS 1, and NHS 2 populations, noting that “race has an influence on both nephrolithiasis (with white populations being more prone to form stones compared with black and Hispanic populations) and CHD (with higher incidence among black populations).” Also missing from the analysis were data on kidney function, which also could have had an effect on outcomes.
The study was supported by the National Institutes of Health. Ferraro had no disclosures. Disclosures for the coauthors are listed in the paper.
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