Lung Cancer Risk Rises With A1c, Falls With Medication

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Lung Cancer Risk Rises With A1c, Falls With Medication

Researchers published the study covered in this summary on Preprints with The Lancet as a preprint that has not yet been peer reviewed.

Key Takeaways

  • Results from a large database study has shown a positive association between prediabetes, diabetes, and incident lung cancer.

  • Treatment with glucose-lowering medications was significantly linked with a reduced rate of incident lung cancer.

  • The relationship between incident lung cancer and A1c was nonlinear with the strongest associations occurring at A1c levels of 32-42 mmol/mol (5.1%-6.0%), levels that fall short of the cutoff for a diagnosis of diabetes, and at the lower end, fall short of the definition of prediabetes.

  • The risk of lung cancer was also more pronounced among participants less than 60 years old, current smokers, and those with a high genetic risk for lung cancer.

This is a summary of a preprint research study, “Associations of glycosylated hemoglobin, pre-diabetes, and diabetes with incident lung cancer: A large prospective cohort study,” by researchers at several different centers in China and the United States on Preprints with The Lancet and provided to you by Medscape. This study has not yet been peer reviewed. The full text of the study can be found here.

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