Metformin May Cause B-12 Deficiency

With the increasing number of people diagnosed with diabetes and peri-diabetes it is important to know and understand the side-effects of the use of Metformin. 

Small studies and case reports have shown that 10 to 30 percent of patients who are prescribed metformin show signs of reduced vitamin B12 absorption leading to clinically significant abnormalities in about 30 percent of cases.

A recent cohort study2 conducted at the University Hospital of Strasbourg, France, examined patients with a diagnosis of metformin-associated cobalamin deficiency and concluded that metformin causes at least 6 percent of the incidence of vitamin B12 deficiency and that resulting hematologic abnormalities and peripheral neuropathy are quite common.

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