Metformin Reduces Weight Gain in Obese Pregnancy, Not LGA

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Metformin Reduces Weight Gain in Obese Pregnancy, Not LGA


Obese nondiabetic women randomly assigned to receive metformin during pregnancy gained less weight than those who did not take the drug, but they were no less likely to have large-for-gestational-age (LGA) neonates, a study published in the February 4 issue of the New England Journal of Medicine shows.
Because metformin improves insulin sensitivity and has been shown to reduce weight gain in pregnant patients with gestational diabetes, Argyro Syngelaki, PhD, from the Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London, United Kingdom, and colleagues hypothesized the drug might lead to a lower median neonatal birth weight z score when given to nondiabetic pregnant women with a body mass index of more than 35 kg/m2.
No between-group differences were observed in any of the additional maternal or neonatal secondary outcomes, including gestational diabetes mellitus, pregnancy-induced hypertension, delivery by cesarean section, postpartum hemorrhage, fetal death before 24 weeks of gestation, stillbirth at 24 weeks of gestation or later, preterm birth before 37 weeks of gestation, birth trauma, an Apgar score of less than 7 at 5 minutes, admission to a level 2 or 3 neonatal unit, or neonatal hypoglycemia.
The secondary outcome findings are limited by the fact that the study was not adequately powered for them, the authors note.
This study was supported by a grant from the Fetal Medicine Foundation. The authors have disclosed no relevant financial relationships.
N Engl J Med. 2016;374:434-443. Abstract

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