safety-lane.com 07105

chiropractic-lane.com
NEWARK
http://bit.ly/1DCt06V

Metformin Use Linked to Increased Dementia, Parkinson’s Risk in Patients With Diabetes

Long-term use of the diabetes medication metformin may increase the risk for neurodegenerative disease in patients with type 2 diabetes mellitus (T2DM), new research suggests.

In a cohort study that followed about 9300 patients with T2DM in Taiwan for up to 12 years, the risk for Parkinson’s disease (PD) or Alzheimer’s dementia was more than double during a 12-year period for those who took metformin vs those who did not — even after adjusting for multiple confounders.

In addition, outcome risks increased progressively with higher dosage and longer duration of treatment.

The results were presented here at AD/PD 2017: The 13th International Conference on Alzheimer’s and Parkinson’s Diseases by Yi-Chun Kuan, MD, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Dr Yi-Chun Kuan

Interestingly, recent research has suggested that use of metformin may protect against neurodegenerative diseases. When asked about that, Dr Kuan told Medscape Medical News that “some studies have actually found positive [outcomes] but some have been negative.” So the researchers wanted to look into this using their own data.

“We’d heard about a possible protective effect from metformin. However, we found the reverse,” she said, but stressed that large-scale, prospective studies in other countries are needed to clarify the results.

AD/PD 2017: International Conference on Alzheimer’s and Parkinson’s Diseases. Abstract 312. Presented March 29, 2017.

via Blogger http://bit.ly/2opZpt4