Migraines May Be a Lipid Disorder

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Migraines May Be a Lipid Disorder

New research has suggested that migraine may be associated with irregularities in the metabolism of certain lipids, opening up new avenues for research into possible treatments and biomarkers for the condition.


The research, published online September 9 in Neurology, . focused on a group of bioactive lipids known as sphingolipids, which are critical components of cell membranes and also play a role in regulating energy homeostasis, apoptosis, and inflammation.


The authors, led by B. Lee Peterlin, DO, from Johns Hopkins University School of Medicine, Baltimore, Maryland, note that neurologic disorders that are the result of severe deficiencies in enzymes that regulate sphingolipid metabolism have long been described (eg, Gaucher disease), and recent studies have suggested that even subtle changes of sphingolipid balance may be involved in dementia, multiple sclerosis, obesity, and pain.


Now they also are reporting a study showing changes in sphingolipid levels in patients with migraine, implicating in particular two sphingolipid subtypes: ceramide and sphingomyelin.


Neurology. Published online September 9, 2015. Article abstract, Comment full text


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