More Evidence Links Arterial Stiffness and Brain Amyloid

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More Evidence Links Arterial Stiffness and Brain Amyloid

Evidence is mounting that arterial stiffness may be the driving force connecting hypertension with amyloid accumulation, and eventually cognitive impairment and dementia.

A previous study, published last year in Neurology, showed that arterial stiffness is related to the amount of β-amyloid (Aβ) present in the brain of nondemented elderly patients, independent of blood pressure and use of antihypertensive medications.

Now, another report by the same investigators has shown that arterial stiffness is also strongly associated with the accumulation of Aβ over almost 2 years in these adults.

“It’s showing that there’s a temporal relationship here in that measuring the arterial stiffness can tell you not just about how much amyloid is there, but also how much it progresses over time,” said lead author Timothy M. Hughes, PhD, postdoctoral fellow Wake Forest School of Medicine, Winstom-Salem, North Carolina.

The new study is published online March 31 in JAMA Neurology.

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