Normal Kind of Memory Loss Worse in Men Than Women

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Normal Kind of Memory Loss Worse in Men Than Women

A new study has found that being male is associated with worse memory and lower hippocampal volume throughout middle and old age in cognitively normal individuals.

Other findings suggest that memory loss and brain shrinkage seen in middle-age is not related to early manifestation of Alzheimer’s disease and that the APOE ε4 gene, which is a risk factor for Alzheimer’s disease, is not predictive of normal memory and brain loss in middle or older age.

The study, published online March 16 in JAMA Neurology, was conducted by a team led by Clifford Jack Jr, MD, Mayo Clinic and Foundation, Rochester, Minnesota.

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