NSAIDs May Protect Against Common Skin Cancer

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NSAIDs May Protect Against Common Skin Cancer


Nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against skin cancer, according to a study published online December 18 in the Journal of Investigative Dermatology.

NSAID use has been associated with lowered risk for colon, lung, breast, and prostate cancers, but evidence for preventing skin cancer has been inconclusive. Chiho Muranushi, PhD, from the School of Population Health, University of Queensland, Brisbane, Australia, and colleagues conducted a meta-analysis of published studies probing the effects of aspirin, nonaspirin NSAIDs, and use of any NSAIDs on preventing squamous cell carcinoma (SCC).

SCC is a prevalent form of skin cancer for which fair-skinned individuals are most susceptible. NSAIDs (including aspirin, ibuprofen, and naproxen) inhibit cyclooxygenase-2 (COX-2), which catalyzes biosynthesis of prostaglandin E2, a mediator of inflammation. COX-2 is overproduced in SCC in response to chronic exposure to ultraviolet radiation.

Limitations of the meta-analysis include the fact that only six of the examined studies were considered high quality, and the chosen studies used different dose units.

J Invest Derm. Published online December 18, 2014. Abstract

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