Obesity Increases Aortic Stiffness And Worsen Middle-Age Memory

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Obesity Increases Aortic Stiffness And Worsen Middle-Age Memory


Being overweight or obese starting in early adulthood was associated with increased aortic stiffness and decreased performance in a memory test at around age 60, in a new study
Researchers investigated this in a 30-year follow-up of participants in the UK Medical Research Council’s National Survey of Health and Development (NSHD)/1946 birth cohort study. The greatest negative effect on later memory was seen in the participants who became obese at the youngest age (in their late 30s), said Dr Stefano Masi (University College London, UK) presenting the findings here at the European Society of Hypertension’s European Society of Hypertension (ESH) 2015 Scientific Sessions.
Subjects who were overweight or obese at age 36 and remained in these weight categories during the follow-up had the worst performance on the word recall test.
However, in individuals who, at any point, dropped one BMI category, memory function and vascular phenotypes (carotid IMT, aortic pulse-wave velocity, and aortic calcification score) were similar to those of normal-weight subjects.
On the other hand, the beneficial effect of weight loss on memory function was lost if people regained weight. “If instead they dropped one category of BMI but regained weight, the score dropped down to the level of the people who had been always [overweight or] obese during follow-up,” Masi said.
This might be explained by changes in insulin resistance, he speculated. “We know insulin resistance is a strong risk factor for Alzheimer’s disease, and when you have a period of weight loss and regain, that is a strong risk factor for insulin resistance,” he said. This could be explored in further research, he suggested.

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