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Obstructive Sleep Apnea Linked to Early Cognitive Decline
Obstructive sleep apnea (OSA) may be associated with early cognitive decline in middle-aged men, new research shows.
In a pilot study out of King’s College London, participants with severe OSA experienced worse executive functioning as well as social and emotional recognition versus healthy controls.
Major risk factors for OSA include obesity, high blood pressure, smoking, high cholesterol, and being middle-aged or older. Because some researchers have hypothesized that cognitive deficits could be driven by such comorbidities, investigators at King’s College London recruited middle-aged men with no medical comorbidities.
“Traditionally, we were more concerned with sleep apnea’s metabolic and cardiovascular comorbidities, and indeed, when cognitive deficits were demonstrated, most were attributed to them, and yet, our patients and their partners/families commonly tell us differently,” lead investigator Ivana Rosenzweig, MD, PhD, of King’s College London, who is also a consultant in sleep medicine and neuropsychiatry at Guy’s and St Thomas’ Hospital, London, UK, told Medscape Medical News.
“Our findings provide a very important first step towards challenging the long-standing dogma that sleep apnea has little to do with the brain — apart from causing sleepiness — and that it is a predominantly non-neuro/psychiatric illness,” added Rosenzweig.
The findings were published online April 6 in Frontiers in Sleep.
Front Sleep. Published online April 6, 2023. Full text
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