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SGLT2: New treatment for heart failure
SGLT2 inhibitors are sodium-glucose Cotransporter-2 Inhibitors that may provide effective protection from medical woes for people with heart failure.
Known as SGLT2 inhibitors, this Type 2 diabetes medication lowers blood sugar by causing the kidneys to remove sugar from the body through the urine. But according to a new study in Annals of Internal Medicine, it is also hugely beneficial for folks with heart failure — regardless of whether or not they have diabetes. The researchers analyzed eight randomized, controlled trials that included more than 15,000 participants. They found that after one year of treatment, SGLT2 inhibitors were associated with a 32% lower risk for hospitalization due to heart failure and a 26% reduction after two years. In addition, the medication reduced the risk of cardiovascular death by 14%. It seems to work by reducing the sodium content in heart cells which reduces a calcium overload that can cause arrhythmias.
But — and there is always a but — the medication does have side effects. The researcher highlighted the risk of genital infections and the Food and Drug Administration says that it also has been associated with kidney problems, leg and foot amputations, decreased bone mineral density and UTIs.
So if you have heart failure, ask your doctor about the benefits and risks of SGLT2 inhibitors for you. And check out the Cleveland Clinic’s “Living with Heart Failure” information at https://cle.clinic/3N9Xsev.
via Blogger https://bit.ly/3w1h52U
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