Statins Linked With Heightened Aggression in Women, But Reductions in Men

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Statins Linked With Heightened Aggression in Women, But Reductions in Men


A new study examining the effects of statin therapy on levels of aggression suggests that men and women may respond differently to the lipid-lowering medications. In men, statin therapy reduced aggression, particularly in younger men, but increased aggression in postmenopausal women.


The increase and decrease in aggression in women and men, respectively, was most consistent and significant among individuals with lower baseline aggression levels, report investigators.


“I don’t think it’s a very common problem,” lead investigator Dr Beatrice Golomb (University of California, San Diego) said in reference to the extent of aggression/irritability among statin-treated patients. In her smaller clinical practice, Golomb said she encountered only a few patients with increased aggression after starting statins to lower cholesterol levels. That said, the “problem definitely occurs, and in some people it can be quite serious.”


To heartwire from Medscape, Golomb explained that low cholesterol levels have been linked with aggression and to violent death/non-illness mortality, such as deaths from suicide, homicide, and accidents, in multiple observational studies. Efforts to lower cholesterol in animal models, such as monkeys, have also shown the animals behave more aggressively with lowered cholesterol levels. Case reports of individuals with aggression/irritability with statins have been documented.

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