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Vitamin D Alone Ineffective for Osteoporosis
This is not the first time we have read about this: Vitamin D MUST be accompanied by Vitamin D to work.
Calcium supplements significantly improved bone health in postmenopausal women in a double-blind, placebo-controlled, randomized trial, but vitamin D supplements alone did not reduce bone turnover or osteoporosis risk.
The trial results are published online September 24 in the Journal of Clinical Endocrinology and Metabolism.
Vitamin D and calcium interact to suppress bone turnover by decreasing parathyroid hormone levels. This can be beneficial in women who are vitamin D deficient. In women who already are receiving the recommended daily allowance of vitamin D, however, the study found there was no advantage to adding a vitamin D supplement.
From December 2008 to April 2011, 159 postmenopausal healthy white women participated in this 6-month, longitudinal study at an ambulatory research center, and 120 completed the study. The 4 study regimens were: double placebo, calcium (1200 mg daily) plus placebo, vitamin D3 (100 μg; 4000 IU) plus placebo, and vitamin D3 and calcium. At baseline and 3 and 6 months, participants gave serum and urine samples after fasting and at 2 hours after a calcium load to measure markers of bone turnover.
When calcium load was given at baseline, serum parathyroid hormone (PTH) and cross-linked C-telopeptide levels fell and urinary calcium excretion rose. Over time, serum cross-linked C-telopeptide and procollagen type I N-terminal propeptide levels decreased with calcium supplementation but remained stable in participants receiving only vitamin D supplementation. The vitamin D groups had a decline in fasting PTH. Compared with the placebo groups, the vitamin D groups had greater suppression of PTH after a calcium load.
“These findings suggest that vitamin D supplements over the recommended dietary allowance…do not protect bone health, whereas calcium supplements do have an effect,” Dr. Aloia said in the news release. “Women do need to be cautious about the possibility of vascular side effects from too much calcium and should consult their physicians about whether their diet is adequate or whether they should take supplements at all.”
J Clin Endocrinol Metabol. Published online September 24, 2013. Abstract
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